SHBG
Measures the protein that binds sex hormones in the blood.
About this test
SHBG is a protein that binds sex hormones and helps explain the relationship between total and free testosterone.
Common reasons for testing
- Clarifying testosterone results when binding-protein changes are suspected.
These are examples of clinical uses. Your history and symptoms determine whether testing is appropriate.
What to expect
A small blood sample is taken from a vein in your arm. You may feel a brief pinch and have mild bruising. Tell the person collecting your sample if you have fainted with needles or take a blood thinner; keep pressure on the site afterward.
Appointment length
Your visit is expected to take about 15 minutes at our West Ashley location.
Categories
Preparation
- Tell the team about hormone treatment, contraception, supplements, pregnancy, and the first day of your last period, if applicable.
- Ask whether a particular collection time or menstrual-cycle day is needed for your clinical question.
- Bring a list of medicines and supplements, including biotin, vitamins, and hormones. Do not stop or change prescribed medicines unless your clinician tells you to.
Order requirement
No outside order needed
Understanding your results
- Liver and thyroid conditions and hormone medicines can affect SHBG. It is interpreted with other hormone tests.
What happens next?
Review the report with your clinician alongside your symptoms, medical history, and earlier results. A value outside the reference range does not always mean disease, and a normal result does not explain every symptom. Confirm who will arrange any repeat or additional testing.
Sources & further reading
This patient summary draws on published clinical literature and professional guidance. Patient resources are identified separately below. Preparation also depends on your specific order and the collecting laboratory or imaging team.
- Testosterone Therapy in Men With Hypogonadism: Endocrine Society Guideline
Journal of Clinical Endocrinology & Metabolism, 2018
Content updated October 11, 2026. General education; individual advice comes from your care team.
Know the cost before your visit
Palmetto Preventive is a direct-pay service. You will see clear payment terms before your booking is finalized — no surprise lab bill.
Self-pay price
One transparent price for this test. Payment terms are presented before your booking is finalized.
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Transparent self-pay pricing — you see the price before you book.
No surprise lab bill after your visit.
If testing is not approved, your payment is refunded in full.
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Start the guided booking. It takes just a few minutes, and you can move back and forth without losing your answers.